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Premedication with intranasal dexmedetomidine in TKA under spinal anaesthesia (TKADEX)
June 2025
Premedication with intranasal dexmedetomidine in TKA under spinal anaesthesia (TKADEX)
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Premedication with intranasal dexmedetomidine in patients undergoing total knee arthroplasty under spinal anaesthesia (TKADEX)-a prospective, double-blinded, randomised controlled trial.
BJA Open . 2025 Mar 3:13:100382.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
One hundred and one patients undergoing elective total knee arthroplasty under spinal anaesthesia were randomized to receive either intranasal dexmedetomidine (n=49) or intranasal saline placebo (n=52). The primary outcome was postoperative pain measured using the numerical rating scale (NRS) during the first 24 hours. Secondary outcomes included postoperative opioid requirements, additional intra...
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