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Premedication with intranasal dexmedetomidine in TKA under spinal anaesthesia (TKADEX)
June 2025
Premedication with intranasal dexmedetomidine in TKA under spinal anaesthesia (TKADEX)
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Premedication with intranasal dexmedetomidine in patients undergoing total knee arthroplasty under spinal anaesthesia (TKADEX)-a prospective, double-blinded, randomised controlled trial.
BJA Open . 2025 Mar 3:13:100382.Synopsis
One hundred and one patients undergoing elective total knee arthroplasty under spinal anaesthesia were randomized to receive either intranasal dexmedetomidine (n=49) or intranasal saline placebo (n=52). The primary outcome was postoperative pain measured using the numerical rating scale (NRS) during the first 24 hours. Secondary outcomes included postoperative opioid requirements, additional intra...
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