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Vol:269 Issue:1 Number:4 ISSN#:2564-2537
ACE Report #14754
Ace Report Cover Arthroplasty

Post-operative Nefopam for Analgesia in Total Knee Arthroplasty

How to Cite

OrthoEvidence. Post-operative Nefopam for Analgesia in Total Knee Arthroplasty. ACE Report. 2022;269(1):4. Available from:

Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1

Does Nefopam Provide Analgesic Effect and Reduce Morphine Consumption After Primary Total Knee Arthroplasty? A Prospective, Double-Blind, Randomized Controlled Trial

J Arthroplasty. 2022 May;37(5): 845-850.

Contributing Authors:
P Pinsornsak S Sukkarnkosol K Boontanapibul

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Eighty-four patients with knee osteoarthritis scheduled for a primary unilateral total knee arthroplasty were randomized to receive 24 hours of continuous infusion of nefopam (n=42) or placebo (n=42). The primary outcome of interest was Visual Analog Scale (VAS) pain scores up to 48 hours post-operation. Secondary outcomes of interest included morphine consumption, adverse events, functional outco...

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