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Post-operative Nefopam for Analgesia in Total Knee Arthroplasty
July 2022
Post-operative Nefopam for Analgesia in Total Knee Arthroplasty
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Does Nefopam Provide Analgesic Effect and Reduce Morphine Consumption After Primary Total Knee Arthroplasty? A Prospective, Double-Blind, Randomized Controlled Trial
J Arthroplasty. 2022 May;37(5): 845-850.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
Eighty-four patients with knee osteoarthritis scheduled for a primary unilateral total knee arthroplasty were randomized to receive 24 hours of continuous infusion of nefopam (n=42) or placebo (n=42). The primary outcome of interest was Visual Analog Scale (VAS) pain scores up to 48 hours post-operation. Secondary outcomes of interest included morphine consumption, adverse events, functional outco...
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