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Volume:2 Issue:7 Number:358 ISSN#:2563-5476
Author Verified
RCT
ACE Report #133
Ace Report Cover Osteoarthritis

Celecoxib vs. diclofenac plus omeprazole for OA or RA treatment with lesser GI risk


How to Cite

OrthoEvidence. Celecoxib vs. diclofenac plus omeprazole for OA or RA treatment with lesser GI risk. ACE Report. 2013;2(7):358. Available from: https://myorthoevidene.com/AceReport/Report/133

Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A

Celecoxib versus omeprazole and diclofenac in patients with osteoarthritis and rheumatoid arthritis (CONDOR): a randomised trial

Lancet. 2010 Jul 17;376(9736):173-9. Epub 2010 Jun 16

Contributing Authors: FK Chan A Lanas J Scheiman MF Berger H Nguyen JL Goldstein

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Synopsis

4484 cardiovascularly healthy patients with a clinical diagnosis of osteoarthritis or rheumatoid arthritis were randomized to be treated with either selective cox-2 inhibitor NSAID (celecoxib) or a combination of non-selective NSAID (diclofenac) and a proton pump inhibitor (omeprazole) for at least 6 months. After 6 months of treatment observation period, the rate of clinically significant GI even...

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