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Celecoxib vs. diclofenac plus omeprazole for OA or RA treatment with lesser GI risk
August 2013
Celecoxib vs. diclofenac plus omeprazole for OA or RA treatment with lesser GI risk
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A
Celecoxib versus omeprazole and diclofenac in patients with osteoarthritis and rheumatoid arthritis (CONDOR): a randomised trial
Lancet. 2010 Jul 17;376(9736):173-9. Epub 2010 Jun 16Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
4484 cardiovascularly healthy patients with a clinical diagnosis of osteoarthritis or rheumatoid arthritis were randomized to be treated with either selective cox-2 inhibitor NSAID (celecoxib) or a combination of non-selective NSAID (diclofenac) and a proton pump inhibitor (omeprazole) for at least 6 months. After 6 months of treatment observation period, the rate of clinically significant GI even...
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