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RCT
ACE Report #10601
Ace Report Cover Osteoarthritis

Synovial biomarkers and clincial scores of Orthovisc versus Hylan G-F20 in knee OA treatment


Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A

Effects of different hyaluronic acid products on synovial fluid levels of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in knee osteoarthritis.

Ann Clin Lab Sci. 2004 Summer;34(3):330-5

Contributing Authors: S Karatay A Kiziltunc K Yildirim RC Karanfil K Senel

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Synopsis

40 patients with knee osteoarthritis were randomized to three weekly injections of either Orthovisc (Anika Therapeutics) or Hylan G-F20 (Synvisc; Genzyme). Primary outcomes were synovial fluid concentrations of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). Clinical outcome on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) was...

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