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ABCB1 C1236T Genotype and Early Postoperative Analgesia in Femoral Fracture Surgery
November 2025
ABCB1 C1236T Genotype and Early Postoperative Analgesia in Femoral Fracture Surgery
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Association of ABCB1 C1236T Gene Polymorphisms With the Postoperative Analgesic Effects of Sufentanil and Morphine in Patients With Femoral Fractures.
J Perianesth Nurs . 2025 Aug;40(4):955-960.Synopsis
Three hundred sixty-nine patients with femoral fractures were randomized to receive either an epidural injection of morphine 1.5 mg at the end of surgery (n = 185) or epidural saline (n = 184), after which all patients received postoperative sufentanil via IV PCA only. The primary outcome was the postoperative NRS pain score, with secondary outcomes including PCA compression frequency, total sufen...
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