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Intranasal Insulin to Prevent Delirium After Hip Fracture Surgery
November 2025
Intranasal Insulin to Prevent Delirium After Hip Fracture Surgery
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Optimal Dose of Intranasal Insulin Administration for Reducing Postoperative Delirium Incidence in Older Patients Undergoing Hip Fracture Surgery.
Am J Geriatr Psychiatry . 2025 Aug;33(8):891-900.Synopsis
One hundred fourty four older patients with hip fracture scheduled for unilateral hip arthroplasty or closed reduction and intramedullary nailing under spinal anesthesia were randomized to receive intranasal saline (Control, n=48), intranasal insulin 20U (I-20, n=48), or intranasal insulin 40U (I-40, n=48) given three times (19:00 the day before surgery, 50 minutes before anesthesia, and 19:00 on ...
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