Intraoperative Clonidine in Spine Surgery
Intraoperative Clonidine in Spine Surgery
Intraoperative Clonidine in Spine Surgery: A Randomised Controlled Trial.
Acta Anaesthesiol Scand . 2025 Jul;69(6):e70048.Synopsis
One hundred twenty-nine patients undergoing surgery for degenerative spine disease were randomized to intraoperative clonidine 3 μg/kg (n=65) or placebo (n=64). The primary outcome was cumulative IV morphine-equivalent consumption in the first 3 hours post-PACU arrival. Secondary outcomes included 6-hour opioid use; pain at rest and with cough at 0–120 min; PONV and Ramsay sedation at 0, 60, and 1...
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