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Intranasal Dexmedetomidine Stabilizes Hemodynamics in TKA Under Spinal Anesthesia
October 2025
Intranasal Dexmedetomidine Stabilizes Hemodynamics in TKA Under Spinal Anesthesia
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Effects of intranasal dexmedetomidine premedication on hemodynamics, oxygenation and bleeding in patients undergoing total knee arthroplasty under spinal anesthesia - a secondary analysis of a prospective, double-blinded, randomized controlled trial (TKAD
J Clin Anesth . 2025 Jul:105:111899.Synopsis
One hundred and one patients with knee osteoarthritis scheduled for unilateral TKA were randomized to receive intranasal dexmedetomidine 1 μg/kg (n=49) or intranasal saline (n=52) about 45 minutes before spinal anesthesia. The primary outcomes were perioperative changes in mean arterial pressure (MAP) and heart rate (HR). Secondary outcomes included systolic/diastolic blood pressure, SpO₂, intraop...
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