LOGIN
Low-Dose Methotrexate for the Treatment of Inflammatory Knee Osteoarthritis
September 2025
Low-Dose Methotrexate for the Treatment of Inflammatory Knee Osteoarthritis
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Low-Dose Methotrexate for the Treatment of Inflammatory Knee Osteoarthritis: A Randomized Clinical Trial.
JAMA Intern Med . 2025 Jul 1;185(7):808-816.Synopsis
Two hundred fifteen patients with inflammatory knee osteoarthritis (OA) and MRI effusion-synovitis were randomized to methotrexate up to 15 mg weekly (n=108) or identical placebo (n=107). The primary outcome of interest was change in knee VAS pain and effusion-synovitis maximal area over 52 weeks. Secondary outcomes of interest included WOMAC (pain, stiffness, function, total), MRI effusion-synovi...
To view the full content, login to your account,
or start your 30-day FREE Trial today.
FREE TRIAL
LOGIN
Forgot Password?
Explore some of our unlocked ACE Reports below!
Learn about our AI Driven
High Impact Search Feature
Our AI driven High Impact metric calculates the impact an article will have by considering both the publishing journal and the content of the article itself. Built using the latest advances in natural language processing, OE High Impact predicts an article’s future number of citations better than impact factor alone.
Continue
Join the Conversation
Please Login or Join to leave comments.