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First-Dose Tolerability of Tramadol-Celecoxib Co-Crystal vs Tramadol in Acute Pain
September 2025
First-Dose Tolerability of Tramadol-Celecoxib Co-Crystal vs Tramadol in Acute Pain
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Adverse Reactions Following First-Dose Administration of Co-Crystal of Tramadol-Celecoxib Versus Tramadol Alone for Moderate-To-Severe Acute Pain.
Pain Ther . 2025 Jun;14(3):1147-1154.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
Three hundred sixty-six patients with moderate-to-severe acute postoperative pain following first metatarsal osteotomy were analyzed after receiving a first dose of CTC 200 mg (n=183) or tramadol 50 mg (n=183). The pupose was to provide a descriptive snapshot of first-dose tolerability. The primary outcome of interest for this post-hoc analysis was the prevalence of study drug–related, opioid-asso...
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