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Periarticular Injection Adds No Benefit With Intrathecal Morphine in TKA
September 2025
Periarticular Injection Adds No Benefit With Intrathecal Morphine in TKA
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Periarticular injection versus placebo in total knee arthroplasty with intrathecal morphine.
Knee . 2025 Jun:54:122-127.Synopsis
Sixty-four patients with primary knee osteoarthritis undergoing unilateral TKA were randomized to receive a standardized PAI (n=34) or placebo saline injection (n=30), with all patients receiving combined spinal–epidural anesthesia including ITM and a multimodal analgesia pathway. The primary outcome was postoperative opioid consumption in morphine milligram equivalents (MME) at 0–24 h, 24–48 h, a...
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