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Allogeneic Disc Cells Improve Pain, Function, and Disc Volume in Lumbar Degeneration
June 2025
Allogeneic Disc Cells Improve Pain, Function, and Disc Volume in Lumbar Degeneration
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Allogeneic Disc Progenitor Cells Safely Increase Disc Volume and Improve Pain, Disability, and Quality of Life in Patients With Lumbar Disc Degeneration-Results of an FDA-Approved Biologic Therapy Randomized Clinical Trial.
Int J Spine Surg . 2024 Jul 4;18(3):237-248.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
Sixty patients with symptomatic single-level lumbar disc degeneration were randomized to receive high-dose disc progenitor cells (n=20), low-dose cells (n=20), vehicle (n=10), or placebo (n=10). The primary outcome of interest was a ≥30% improvement in visual analog scale (VAS) pain score at 52 weeks. Secondary outcomes included changes in Oswestry Disability Index (ODI), EQ-5D quality of life sco...
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