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Vapocoolant Spray Application During Intra-Articular Knee Injection
June 2025
Vapocoolant Spray Application During Intra-Articular Knee Injection
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Vapocoolant spray application during intra-articular knee injection: myth or reality?: A prospective randomized controlled trial.
Medicine (Baltimore). 2025 Feb 21;104(8):e41704.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
One hundred sixty-five patients with Kellgren-Lawrence grade II–III–IV knee osteoarthritis were randomized to receive vapocoolant spray (n=55), placebo saline spray (n=55), or no analgesic treatment (n=55) prior to intra-articular hyaluronic acid injections. The primary outcome was pain during needle penetration assessed by a 100-mm visual analog scale (VAS). Secondary outcomes included preinjecti...
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