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Esketamine–Dexmedetomidine and Early Cognitive Function After Lumbar Surgery in Elderly
April 2025
Esketamine–Dexmedetomidine and Early Cognitive Function After Lumbar Surgery in Elderly
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Effects of Esketamine Combined with Dexmedetomidine on Early Postoperative Cognitive Function in Elderly Patients Undergoing Lumbar Spinal Surgery: A Double-Blind Randomized Controlled Clinical Trial.
Drug Des Devel Ther . 2024 Nov 27:18:5461-5472.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
One hundred fifty-nine elderly patients undergoing lumbar spine surgery were randomized to receive esketamine plus dexmedetomidine (ED group, n=53), esketamine alone (E group, n=53), or dexmedetomidine alone (D group, n=53). The primary outcome was the incidence of postoperative cognitive dysfunction (POCD) on the first postoperative day. Secondary outcomes included POCD on the third day, serum ne...
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