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Duloxetine as an Analgesic in Patients Who Do Not Have Central Sensitivity Undergoing Bilateral TKA
February 2025
Duloxetine as an Analgesic in Patients Who Do Not Have Central Sensitivity Undergoing Bilateral TKA
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Duloxetine as an Analgesic in Patients Who Do Not Have Central Sensitivity Undergoing Single-Setting, Bilateral Total Knee Arthroplasty: A Prospective, Double-Blinded, Randomized, Placebo-Controlled Trial.
J Arthroplasty . 2024 Aug;39(8):2055-2060.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
One hundred and six patients undergoing bilateral total knee arthroplasty (TKA) were randomized to receive either 20 mg of duloxetine (n=53) or a placebo (n=53) from preoperative day 2 to postoperative day 28. The primary outcome of interest was pain control, measured using the visual analogue scale (VAS) at rest (rVAS) and during mobilization (mVAS). Secondary outcomes included additional non-st...
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