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AAHKS 2024: Duloxetine Does Not Affect Opioid Use or Outcomes after Primary TKA
January 2025
AAHKS 2024: Duloxetine Does Not Affect Opioid Use or Outcomes after Primary TKA
Study Type:Randomized Trial
OE Level Evidence:N/A
Journal Level of Evidence:N/A
Duloxetine Does Not Affect Opioid Use or Outcomes after Primary TKA: A Randomized Controlled Trial
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CONFERENCE ACE REPORTS
This ACE Report is a summary of a conference presentation or abstract. The information provided has limited the ability to provide an accurate assessment of the risk of bias or the overall quality. Please interpret the results with caution as trials may be in progress and select results may have been presented.
Synopsis
One hundred fifty-one patients undergoing total knee arthroplasty were randomized to receive 30 mg of duloxetine daily (n=82) or placebo (n=69) from one week preoperatively to six weeks postoperatively. The primary outcome was daily opioid consumption measured as morphine milliequivalents (MME) in the first two weeks after surgery. Secondary outcomes included sleep quality and duration in the same...
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