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AAHKS 2024: ATX-101 provides sustained pain relief in TKA patients

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January 2025

AAHKS 2024: ATX-101 provides sustained pain relief in TKA patients

Vol: 307| Issue: 1| Number:22| ISSN#: 2564-2537
Study Type:Randomized Trial
OE Level Evidence:N/A
Journal Level of Evidence:N/A

ATX-101 provides sustained pain relief in TKA patients: results of a multicentre double-blind RCT

Contributing Authors:
Hemant Pandit D Liu A Shimmin G Ludbrook S Hall Fathi Abuzgaya Adam Gridley David J Hewitt

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CONFERENCE ACE REPORTS

This ACE Report is a summary of a conference presentation or abstract. The information provided has limited the ability to provide an accurate assessment of the risk of bias or the overall quality. Please interpret the results with caution as trials may be in progress and select results may have been presented.

Synopsis

One hundred and twelve patients undergoing total knee arthroplasty were randomized to receive either ATX101 (1000 mg, n=37 or 1500 mg, n=37) or a control treatment (bupivacaine, n=34 or placebo, n=4). The primary outcome of interest was the area under the curve (AUC) of pain intensity measured by the Numerical Rating Scale for Resting Pain (NRS-R) from 30 minutes to 8 days. Secondary outcomes incl...

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