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Intravenous Zoledronic Acid on TKA in Patients With Symptomatic Knee Osteoarthritis
March 2025
Intravenous Zoledronic Acid on TKA in Patients With Symptomatic Knee Osteoarthritis
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Effect of Intravenous Zoledronic Acid on Total Knee Replacement in Patients With Symptomatic Knee Osteoarthritis and Without Severe Joint Space Narrowing: A Prespecified Secondary Analysis of a Two-Year, Multicenter, Double-Blind, Placebo-Controlled Clinical Trial
Arthritis Rheumatol. 2024 Jul;76(7):1047-1053.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
Two hundred twenty-two patients with symptomatic knee osteoarthritis and without severe joint space narrowing were randomized to receive either intravenous zoledronic acid (5 mg annually, n=113) or placebo (n=109). The primary outcome of interest was the risk of total knee replacement. Secondary outcomes included the incidence of total knee replacement in the study knee, total knee replacement in ...
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