One hundred patients undergoing primary total knee arthroplasty (TKA) for primary osteoarthritis were randomized to receive either two-dose intravenous tranexamic acid (n=50) or placebo (n=50). The primary outcome of interest was total blood loss within 72 hours postoperatively. Secondary outcomes included intraoperative blood loss, postoperative blood loss, hidden blood loss, need for allogeneic ...