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Efficacy & Safety Of Diacerein & Celecoxib Combination Therapy For Knee OA in Older Adults
June 2025
Efficacy & Safety Of Diacerein & Celecoxib Combination Therapy For Knee OA in Older Adults
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Efficacy and safety of diacerein and celecoxib combination therapy for knee osteoarthritis: A double-blind, randomized, placebo-controlled prospective study.
Medicine (Baltimore) . 2023 Sep 29;102(39):e35317.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
Seventy-one patients with primary knee osteoarthritis were randomized to receive either diacerein and celecoxib combination therapy (n=25), diacerein and placebo (n=24), or celecoxib and placebo (n=22). The primary outcome was the change in visual analog scale (VAS) score after 12 weeks. Secondary outcomes included WOMAC pain, stiffness, and physical function scores, and safety outcomes. Outcomes ...
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