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Acetaminophen Plus Ibuprofen, Codeine, Hydrocodone, or Oxycodone for Musculoskeletal Pain Relief

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Ace Report Cover
April 2021

Acetaminophen Plus Ibuprofen, Codeine, Hydrocodone, or Oxycodone for Musculoskeletal Pain Relief

Vol: 19| Issue: 1| Number:4| ISSN#: 2564-2537
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1

A Randomized Trial Comparing the Efficacy of Five Oral Analgesics for Treatment of Acute Musculoskeletal Extremity Pain in the Emergency Department

Ann Emerg Med. 2021 Mar;77(3): 345-356.

Contributing Authors:
PE Bijur BW Friedman E Irizarry AK Chang EJ Gallagher

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Synopsis

Six hundred patients presenting to the 2 urban center emergency departments with acute musculoskeletal pain in ≥1 extremities lasting for >7 days and which the attending physician was willing to administer oral analgesics were randomized to receive either of the 5 oral analgesic combinations: (1) 400 mg ibuprofen plus 1,000 mg acetaminophen; (2) 800 mg ibuprofen plus 1,000 mg acetaminophen; (3) 30...

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