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Romosozumab in Skeletally Mature Adults with a Fresh Unilateral Tibial Diaphyseal Fracture
March 2025
Romosozumab in Skeletally Mature Adults with a Fresh Unilateral Tibial Diaphyseal Fracture
Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:1
Romosozumab in Skeletally Mature Adults with a Fresh Unilateral Tibial Diaphyseal Fracture: A Randomized Phase-2 Study
J Bone Joint Surg Am. 2020 Aug 19;102(16):1416-1426.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
Four hundred two patients with fresh unilateral tibial diaphyseal fractures were randomized 3:1 to receive either romosozumab (n=299) or placebo (n=103). Patients in the romosozumab group were further divided into nine dosing regimens, receiving subcutaneous injections on postoperative day 1 and at weeks 2, 6, and 12. The primary outcome was the time to radiographic healing, defined as bridging of...
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