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Bisphosphonates in revision THA ineffective in altering pseudomembrane cytokine expression
July 2013
Bisphosphonates in revision THA ineffective in altering pseudomembrane cytokine expression
Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A
Effect of alendronate on pseudomembrane cytokine expression in patients with aseptic osteolysis
J Arthroplasty. 2010 Sep;25(6):958-63Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
10 patients, scheduled for revision hip arthroplasty due to aseptic osteolysis, were randomized into two groups, one received the alendronate for 8 weeks prior to surgery and another received placebo. The pseudo membrane was harvested at the time of surgery and immunohistochemistry and various cytokine expressions were tested in the two groups. In conclusion, the alendronate therapy prior to revis...
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