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IORA prophylaxis achieves greater vancomycin tissue concentration vs IV administration in TKA
August 2018
IORA prophylaxis achieves greater vancomycin tissue concentration vs IV administration in TKA
Study Type:Randomized Trial
OE Level Evidence:2
Journal Level of Evidence:N/A
The AAHKS Clinical Research Award: Intraosseous Regional Prophylaxis Provides Higher Tissue Concentrations in High BMI Patients in Total Knee Arthroplasty: A Randomized Trial
J Arthroplasty. 2018 Jul;33(7S):S13-S18. doi: 10.1016/j.arth.2018.03.013Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
22 patients with a BMI over 35 and scheduled for total knee arthroplasty were randomized to either intraosseous regional administration (IORA) vancomycin 500mg or intravenous vancomycin 15mg/kg. Intraoperative samples of subcutaneous fat and femoral bone were obtained and tested for concentrations of vancomycin. Results demonstrated significantly greater concentrations of vancomycin in the IORA gr...
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