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AAOS 2016: Topical injection and infusion for pain management in lumbar spine surgery

RCT Spine Axial Skeleton Lumbar Pain Bupivacaine Morphine Adrenalin Control Infusion Topical Injection - Hide

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IV & topical TXA similarly safe & effective for reducing blood loss and transfusion in TKA

J Orthop. 2016 Mar 26;13(3):127-31

RCT Arthroplasty Lower Extremity Knee Tranexamic Acid Blood Loss Topical TXA Transfusion - Hide

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Combined Topical & IV TXA superior to topical TXA alone for reducing blood loss in TKA

J Arthroplasty. 2015 May;30(5):776-80

RCT Arthroplasty Osteoarthritis Lower Extremity Knee Arthritis Tranexamic Acid Blood Loss Control IV Saline Transfusion TXA - Hide

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Addition of diluted epinephrine to topical TXA for reducing blood loss in THA

J Arthroplasty. 2015 Dec;30(12):2196-200

RCT Arthroplasty Lower Extremity Hip Bone Femur Head DePuy Tranexamic Acid Epinephrine Injection Blood Loss Saline Topical TXA - Hide

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Combined IV & topical TXA reduces blood loss and transfusion rate in THA

J Bone Joint Surg Am. 2016 Jun 15;98(12):983-91

RCT Arthroplasty Osteoarthritis Lower Extremity Hip Bone Femur Head Arthritis Tranexamic Acid Intravenous Injection IV TXA - Hide

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Topical TXA and IV TXA similarly effective in reducing blood loss in tourniquetless TKA

J Arthroplasty. 2016 Nov;31(11):2465-2470

RCT Arthroplasty Osteoarthritis Lower Extremity Knee Arthritis Injection Topical Tranexamic Acid Tourniquet TXA - Hide

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Thrombin-based topical haemostatic agent effective for TKR revision surgery

Knee Surg Sports Traumatol Arthrosc. 2015 Nov;23(11):3337-42

RCT Arthroplasty Lower Extremity Knee Baxter Blood Loss Control Floseal Haemostatic Revision Surgery Thrombin TKR Transfusion - Hide

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Assessing the efficacy of topical diclofenac in the treatment of knee osteoarthritis pain

J Rheumatol. 2006 Mar;33(3):567-73

Meta-analysis Osteoarthritis Lower Extremity Knee Arthritis Pain Oral Diclofenac Placebo Preparation Topical Diclofenac - Hide

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Topical NSAIDs demonstrate significant reduction in pain versus placebo for treatment of knee OA

J Rheumatol. 2006 Sep;33(9):1841-4

Meta-analysis Osteoarthritis Lower Extremity Knee Arthritis Inflammation Pain Gel Non-Steroid Nonsteroidal NSAID Ointment Placebo Reduction Topical Nsaids - Hide

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Topical TXA Reduces Blood Loss and Improves Blood Chemistry After Total Knee Replacement Surgery

Eur J Orthop Surg Traumatol. 2020 Aug-01;():. 10.1007/s00590-020-02656-9

RCT General Orthopaedics Appendicular Lower Extremity Knee Rottapharm Control Normal Saline Tranexamic Acid (TXA) Antifibrinolytic agent Antifibrinolytic agent Intra-articular (IA) injection Intra-articular (IA) injection Amchafibrin - Hide

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Topical TXA found safe and effective for reduction of blood loss and transfusion in TKA

Orthopedics. 2015 May 1;38(5):315-24.

Meta-analysis Arthroplasty Lower Extremity Knee Blood Loss Control Reduction Replacement TKA TKR Topical Tranexamic Acid Topical TXA Transfusions - Hide

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Topical NSAIDs equally effective as oral NSAIDs for knee pain, with fewer adverse effects

BMJ. 2008 Jan 19;336(7636):138-42. Epub 2007 Dec 4.

RCT Osteoarthritis Lower Extremity Knee Arthritis Pain Oral Ibuprofen - Hide

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Topical flaxseed oil versus placebo for treatment of knee osteoarthritis

Complement Ther Clin Pract. 2018 May;31:302-307

RCT Osteoarthritis Lower Extremity Knee Arthritis Oil Placebo - Hide

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AAOS: Topical tranexamic acid effacacious method for blood loss management in TKA

RCT Arthroplasty Lower Extremity Knee Blood Loss Implantation Placebo Saline Topical Tranexamic Acid - Hide

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AAOS2017: Blood loss and transfusion rate similar with intravenous and topical TXA in THA

RCT Arthroplasty Lower Extremity Hip Tranexamic Acid Topical Infiltration - Hide

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Massage plus topical analgesic more effective than massage alone for hand arthritis pain

J Bodyw Mov Ther. 2014 Jul;18(3):322-5

RCT Hand & Wrist Women Upper Extremity Hand Arthritis Pain Massage Therapy Program Topical Analgesic - Hide

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Topical and intravenous tranexamic acid equally effective in total knee arthroplasty

Knee. 2014 Dec;21(6):987-993

Meta-analysis Arthroplasty Lower Extremity Knee Blood Loss Intravenous Tranexamic Acid Replacement TKA TKR Transfusion - Hide

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Topical TXA reduces blood loss compared to IV TXA in bilateral total knee arthroplasty

J Arthroplasty. 2016 Jul;31(7):1442-8

RCT Arthroplasty Osteoarthritis Lower Extremity Knee Arthritis Stryker Tranexamic Acid Bilateral Blood Loss IV TXA Topical TXA - Hide

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COA: Topical anesthetic does not reduce intraosseous pin removal pain in children

RCT Pediatric Orthopaedics Children Pain Lidocaine Anaesthesia Anesthetic Cream Percutaneous Intraosseous Pin Placebo - Hide

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Efficacy of topical diclofenac preparation in managing symptomatic knee osteoarthritis

CMAJ. 2004 Aug 17;171(4):333-8

RCT Osteoarthritis Lower Extremity Knee Arthritis Dimethaid Health Care Control Diclofenac Sodium Topical Diclofenac Vehicle - Hide

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AAOS 2016: Topical injection and infusion for pain management in lumbar spine surgery

IV & topical TXA similarly safe & effective for reducing blood loss and transfusion in TKA

Combined Topical & IV TXA superior to topical TXA alone for reducing blood loss in TKA

Addition of diluted epinephrine to topical TXA for reducing blood loss in THA

Combined IV & topical TXA reduces blood loss and transfusion rate in THA

Topical TXA and IV TXA similarly effective in reducing blood loss in tourniquetless TKA

Thrombin-based topical haemostatic agent effective for TKR revision surgery

Assessing the efficacy of topical diclofenac in the treatment of knee osteoarthritis pain

Topical NSAIDs demonstrate significant reduction in pain versus placebo for treatment of knee OA

Topical TXA Reduces Blood Loss and Improves Blood Chemistry After Total Knee Replacement Surgery

Topical TXA found safe and effective for reduction of blood loss and transfusion in TKA

Topical NSAIDs equally effective as oral NSAIDs for knee pain, with fewer adverse effects

Topical flaxseed oil versus placebo for treatment of knee osteoarthritis

AAOS: Topical tranexamic acid effacacious method for blood loss management in TKA

AAOS2017: Blood loss and transfusion rate similar with intravenous and topical TXA in THA

Massage plus topical analgesic more effective than massage alone for hand arthritis pain

Topical and intravenous tranexamic acid equally effective in total knee arthroplasty

Topical TXA reduces blood loss compared to IV TXA in bilateral total knee arthroplasty

COA: Topical anesthetic does not reduce intraosseous pin removal pain in children

Efficacy of topical diclofenac preparation in managing symptomatic knee osteoarthritis

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