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Multi-injection HA appears to be more effective than single-injection HA versus saline for knee OA

BMC Musculoskelet Disord. 2017 Dec 21;18(1):542

Meta-analysis Osteoarthritis Lower Extremity Knee Arthritis Ferring HA Hyaluronic Acid Injections Placebo Injection Placebo Saline Single Injection - Hide

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Addition of IA steroid injection to exercise not efficacious for knee OA inflammation

Osteoarthritis Cartilage. 2016 May;24(5):814-21

RCT Osteoarthritis Lower Extremity Knee Joint Tibiofemoral Arthritis Inflammation Pfizer Methylprednisolone Lidocaine Steroid Injection Corticosteroid Depomedrol Exercise IA Injection Isotonic Saline Physical Therapy Placebo Ultrasound - Hide

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IA glucocorticioid not associated with decrease in synovitis when compared to IA saline for knee OA

Osteoarthritis Cartilage. 2017 Apr;25(4):481-491

RCT Osteoarthritis Lower Extremity Knee Arthritis Pain Synovitis Methylprednisolone Lidocaine Glucocorticoid Injection IA Saline Ultrasound-Guided - Hide

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Higher OMERACT-OARSI response rate following IA-HA injection vs steroid or placebo

Br J Sports Med. 2016 Jan;50(2):84-92

Meta-analysis Osteoarthritis Lower Extremity Knee Arthritis Corticosteroid HA Injection IA-HA Injections Of Hyaluronic Acid Low-Molecular-Weight Placebo Saline Steroid Viscosupplementation - Hide

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Single IA injection of NASHA hyaluronic acid not effective overall for pain in knee OA

Curr Med Res Opin. 2014 Feb;30(2):279-86

RCT Osteoarthritis Lower Extremity Knee Arthritis Pain Q-Med AB Smith & Nephew Durolane Hyaluronic Acid Injection Of NASHA Saline - Hide

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Comparison for IA corticosteroid versus saline injection following lavage for knee OA

Rheumatology (Oxford). 2003 Dec;42(12):1477-85

RCT Osteoarthritis Lower Extremity Knee Arthritis Arthroscopy Injection IA Corticosteroid Lavage Methylprednisolone Acetate Placebo Saline - Hide

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IA injection of morphine + bupivacaine vs. morphine alone for analgesia after arthroscopy

PLoS One. 2015 Oct 16;10(10):e0140512

Meta-analysis Sports Medicine Lower Extremity Knee Pain Bupivacaine Morphine Analgesia Anterior Cruciate Arthroscopic Arthroscopy IA Injection Immediate Single-Dose - Hide

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Single-Dose IA ropivacaine reduces pain up to 8 hours post arthroscopic knee surgery

Knee Surg Sports Traumatol Arthrosc. 2016 May;24(5):1651-9

Meta-analysis Arthroplasty Lower Extremity Knee Pain Analgesic Anterior Cruciate Arthroscopic Arthroscopy IA Ropivacaine Placebo Post-Operative Post-Surgery Single-Dose - Hide

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Adjunct periarticular lidocaine-corticosteroid injection to IAHA improves pain in knee OA

Knee Surg Sports Traumatol Arthrosc. 2016 Nov;24(11):3653-3660

RCT Osteoarthritis Lower Extremity Knee Arthritis Pain Adant Schering Schering-Plough Lidocaine Corticosteroid Injection Hyaluronic Acid IAHA Sodium Hyaluronate - Hide

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IA-HA injection as adjunct to microfracture surgery for osteochondral lesions of the talus

Knee Surg Sports Traumatol Arthrosc. 2016 Apr;24(4):1243-9

RCT Foot & Ankle Lesion Lower Extremity Bone Talus Seikagaku Artz Injections HA Injection Hyaluronic Acid IA-HA Microfracture Surgery MRI - Hide

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Single-dose intra-articular bupivacaine significantly reduces pain after knee arthroscopy

Knee Surg Sports Traumatol Arthrosc. 2014 Jul;22(7):1517-28

Meta-analysis General Orthopaedics Lower Extremity Knee Pain Bupivacaine Analgesia Analgesic Arthroscopic Surgery Arthroscopy IA Placebo Reduction Single-Dose - Hide

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Safety and efficacy of IA bupivacaine for pain management after total joint arthroplasty

BMJ Open. 2016 Jul 12;6(7):e011325

Meta-analysis Arthroplasty TJA Pain IA Bupivacaine Intraarticular Bupivacaine Narcotic Placebo Replacement - Hide

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OARSI 2016: Allogenic mesenchymal precursor cells + hyaluronan injection after ACL repair

RCT Trauma Joint Ligament Hyaluronan Allogeneic Anterior Cruciate HA Reconstruction Single Injection - Hide

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Steroid injection into rotator interval favoured over IA & subacromial injection for frozen shoulder

Am J Sports Med. 2018 Mar;46(3):663-670

RCT Shoulder & Elbow Capsulitis Upper Extremity Shoulder Bone Subacromial Pain Lidocaine Corticosteroid IA Triamcinolone Acetonide Ultrasound-Guided Injection - Hide

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Intra-articular hylastan vs intra-articular steroid in knee OA treatment

Knee Surg Sports Traumatol Arthrosc. 2014 Jul;22(7):1684-92

RCT Osteoarthritis Lower Extremity Knee Arthritis Genzyme Hylastan Arthrocentesis IA Injection Of Methylprednisolone Acetate Steroid - Hide

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ISAKOS2017: IA TXA reduces postoperative bleeding in anterior cruciate ligament reconstruction

RCT Sports Medicine Joint Ligament Hemarthrosis Tranexamic Acid Anterior Cruciate Injection Control IA TXA Reconstruction - Hide

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Efficacy of joint lavage and/or IA CS injection in knee OA treatment; 2x2 factorial trial

Arthritis Rheum. 1999 Mar;42(3):475-82

RCT Osteoarthritis Lower Extremity Knee Arthritis Roussel Injection IA Placebo Lavage - Hide

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Multi-injection HA appears to be more effective than single-injection HA versus saline for knee OA

Addition of IA steroid injection to exercise not efficacious for knee OA inflammation

IA glucocorticioid not associated with decrease in synovitis when compared to IA saline for knee OA

Higher OMERACT-OARSI response rate following IA-HA injection vs steroid or placebo

Single IA injection of NASHA hyaluronic acid not effective overall for pain in knee OA

Comparison for IA corticosteroid versus saline injection following lavage for knee OA

IA injection of morphine + bupivacaine vs. morphine alone for analgesia after arthroscopy

Single-Dose IA ropivacaine reduces pain up to 8 hours post arthroscopic knee surgery

Adjunct periarticular lidocaine-corticosteroid injection to IAHA improves pain in knee OA

IA-HA injection as adjunct to microfracture surgery for osteochondral lesions of the talus

Single-dose intra-articular bupivacaine significantly reduces pain after knee arthroscopy

Safety and efficacy of IA bupivacaine for pain management after total joint arthroplasty

OARSI 2016: Allogenic mesenchymal precursor cells + hyaluronan injection after ACL repair

Steroid injection into rotator interval favoured over IA & subacromial injection for frozen shoulder

Intra-articular hylastan vs intra-articular steroid in knee OA treatment

ISAKOS2017: IA TXA reduces postoperative bleeding in anterior cruciate ligament reconstruction

Efficacy of joint lavage and/or IA CS injection in knee OA treatment; 2x2 factorial trial

AAOS2019: IA corticosteroid versus NSAID in knee osteoarthritis treatment

ISAKOS2017: Efficacy of IA steroid injection in the treatment of frozen shoulder

IA bupivacaine and morphine reduces pain in arthroscopic knee surgery compared to placebo

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