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TKA: Interval clamping drain provides greater bleeding control than non-clamping methods

Arch Orthop Trauma Surg. 2012 Jul;132(7):1059-63. doi: 10.1007/s00402-012-1501-z. Epub 2012 Mar 13

RCT Arthroplasty Osteoarthritis Lower Extremity Knee Arthritis Control Fitted Interval Clamping Non-Clamping TKA Vacuum Drain - Hide

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No advantage shown for drainage-clamping methods following TKA

J Arthroplasty. 2010 Dec;25(8):1240-5

Meta-analysis Arthroplasty Lower Extremity Knee Blood Loss Blood Transfusion Control Conventional Delayed Drainage Non-Clamping Primary TKA Reduction Replacement - Hide

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TKA: Drain-clamping with tranexamic acid decreased drained blood volume/ transfusions

BMC Musculoskelet Disord. 2012 Jul 20;13:124. doi: 10.1186/1471-2474-13-124

RCT Arthroplasty Lower Extremity Knee Arthritis Tranexamic Acid Blood Drain Non-Clamping Placebo TKA - Hide

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Reduced blood loss during TKA with drain clamping and injection of saline with adrenaline

J Bone Joint Surg Br. 2006 Jan;88(1):49-53

RCT Arthroplasty Lower Extremity Knee Stryker Adrenaline Blood Loss Drain Clamping Injection Of Saline Post-Operative Blood Salvage Re-Infusion TKA - Hide

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Clamping drainage reduces blood loss and transfusions after TKA

Int Orthop. 2009 Oct;33(5):1275-8. Epub 2008 Oct 17.

RCT Arthroplasty Osteoarthritis Lower Extremity Knee Arthritis Clamped Drainage Clamping Conventional Suction Drainage TKA - Hide

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TKA: Non-continuous drainage is equally safe, yet more effective than continuous drainage

Int Orthop. 2014 Feb;38(2):361-71. doi: 10.1007/s00264-013-2105-0. Epub 2013 Sep 19.

Meta-analysis Arthroplasty Wound Lower Extremity Knee Tranexamic Acid Information TKA Wound Drainage - Hide

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Local Injection of Tranexamic Acid vs Drain Clamping in Total Knee Arthroplasty

BMC Musculoskelet Disord. 2022 01-Feb;():. 10.1186/s12891-022-05058-6

RCT Arthroplasty Osteoarthritis Appendicular Lower Extremity Knee Clamped Drainage Surgical Drain Normal Saline Tranexamic Acid (TXA) Antifibrinolytic agent Antifibrinolytic agent Surgical drain - Hide

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Four-hour postoperative drain clamping does not reduce blood loss following TKA

Knee Surg Sports Traumatol Arthrosc. 2013 Dec;21(12):2831-6. doi: 10.1007/s00167-012-2253-6. Epub 2012 Oct 23

RCT Arthroplasty Wound Lower Extremity Knee 3M Howmedica Stryker Epinephrine Injection Blood Loss Clamped Drain Clamping - Hide

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OTA 2022: PAIN Trial - Effect of NSAIDs and Pregabalin on Non-Union in Trauma Patients

RCT Trauma Lower Extremity Ankle Bone Calcaneus Femur Humerus Talus Tibia Shaft Supracondylar Plafond Plateau Fracture Pain Pregabalin NSAID Nsaids Oral Placebo Post-Surgery - Hide

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TKA: Tranexamic acid reduces blood loss without increasing risk of DVT

J Arthroplasty. 2012 Jan;27(1):105-8. Epub 2011 Mar 23

RCT Arthroplasty Lower Extremity Knee Tranexamic Acid Blood Carbazochrome Sodium Sulfonate Hydrate Drain-Clamping Saline TKA - Hide

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rhBMP-7 results in higher union rates compared to PRP in treatment of long bone non-unions

Injury. 2008 Dec;39(12):1391-402. Epub 2008 Nov 22

RCT Trauma Fracture Platelet-Rich Plasma PRP Recombinant Bone Morphogenic Protein - Hide

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Non-operative treatment is non-inferior to operative treatment of thoracolumbar fractures

Clin Orthop Relat Res. 2012 Feb;470(2):567-77. Epub 2011 Nov 5

Meta-analysis Spine Fracture Nonoperative Non-Operative Operative Management - Hide

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OTA 2022: MOON Trial - Operative vs. Non-operative Fixation of Associated Medial Malleolar Fractures

RCT Foot & Ankle Lower Extremity Ankle Bone Fibula Malleolus Fracture Non-Operative Operative Fixation Stabilization Surgical Fixation - Hide

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Treatment of 3 or 4-part proximal humerus fracture: surgical vs. non-surgical treatment

J Invest Surg. 2015 Aug;28(4):215-24.

Meta-analysis Trauma Bone Humerus Fracture Arthroplasty Conservative Consultation Control Hemiarthroplasty Intramedullary Nail Invasive Locking Plate Non-Surgical Osteosynthesis Prosthesis Screws - Hide

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Patellar eversion versus non-eversion in otherwise standardized TKA procedures

Knee Surg Sports Traumatol Arthrosc. 2016 Mar;24(3):921-30

Meta-analysis Arthroplasty Lower Extremity Knee Bone Patella Everted Patellar Eversion Primary TKA Replacement Retraction Standardized Technique TKR - Hide

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AAOS 2016: Non-particulate and particulate steroids equally effective for radiculopathy

Meta-analysis Spine Cervical Lumbar Radiculopathy Injections Epidural Post-Injection Reduction Steroid Transforaminal - Hide

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Extended-release metoprolol in the prevention of CV complications in non-cardiac surgery

Lancet. 2008 May 31;371(9627):1839-47. doi: 10.1016/S0140-6736(08)60601-7. Epub 2008 May 12.

RCT General Orthopaedics AstraZeneca Metoprolol Extended-Release Placebo - Hide

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Patellar eversion & non-eversion have similar clinical outcomes in total knee arthroplasty

Knee Surg Sports Traumatol Arthrosc. 2016 Jan;24(1):141-7

Meta-analysis Arthroplasty Lower Extremity Knee Bone Patella Negative Patellar Eversion Prosthesis Replacement - Hide

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Region-specific and non-specific spinal manipulative therapy for chronic low back pain

Phys Ther. 2013 Jun;93(6):748-56. doi: 10.2522/ptj.20120256. Epub 2013 Feb 21.

RCT Physical Therapy & Rehab Low Back Axial Skeleton Spine Spine Back Pain Non-Region-Specific Region-Specific SMT Region-Specific Spinal Manipulation Spinal Manipulative Therapy - Hide

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Operative vs. Non-operative treatment of calcaneal fractures

J Bone Joint Surg Am. 2013 Aug 7;95(15):1351-7

RCT Foot & Ankle Lower Extremity Bone Calcaneus Fracture Non-Operative - Hide

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TKA: Interval clamping drain provides greater bleeding control than non-clamping methods

No advantage shown for drainage-clamping methods following TKA

TKA: Drain-clamping with tranexamic acid decreased drained blood volume/ transfusions

Reduced blood loss during TKA with drain clamping and injection of saline with adrenaline

Clamping drainage reduces blood loss and transfusions after TKA

TKA: Non-continuous drainage is equally safe, yet more effective than continuous drainage

Local Injection of Tranexamic Acid vs Drain Clamping in Total Knee Arthroplasty

Four-hour postoperative drain clamping does not reduce blood loss following TKA

OTA 2022: PAIN Trial - Effect of NSAIDs and Pregabalin on Non-Union in Trauma Patients

TKA: Tranexamic acid reduces blood loss without increasing risk of DVT

rhBMP-7 results in higher union rates compared to PRP in treatment of long bone non-unions

Non-operative treatment is non-inferior to operative treatment of thoracolumbar fractures

OTA 2022: MOON Trial - Operative vs. Non-operative Fixation of Associated Medial Malleolar Fractures

Treatment of 3 or 4-part proximal humerus fracture: surgical vs. non-surgical treatment

Patellar eversion versus non-eversion in otherwise standardized TKA procedures

AAOS 2016: Non-particulate and particulate steroids equally effective for radiculopathy

Extended-release metoprolol in the prevention of CV complications in non-cardiac surgery

Patellar eversion & non-eversion have similar clinical outcomes in total knee arthroplasty

Region-specific and non-specific spinal manipulative therapy for chronic low back pain

Operative vs. Non-operative treatment of calcaneal fractures

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