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Periarticular multimodal drug injections effective and safe analgesic for TKA

Knee Surg Sports Traumatol Arthrosc. 2014 Aug;22(8):1949-57. doi: 10.1007/s00167-013-2566-0. Epub 2013 Jun 20.

Meta-analysis Arthroplasty Lower Extremity Knee Epinephrine Anaesthesia Analgesic Injections Corticosteroid Local Infiltration Periarticular Multimodal Placebo Replacement TKA - Hide

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Multimodal drug cocktail an effective analgesic treatment for ACL reconstruction

Arthroscopy. 2012 May;28(5):649-57. Epub 2012 Jan 26

RCT Sports Medicine Bone Patella Joint Ligament Pain Ropivacaine Injection Periarticular Multimodal Reconstruction - Hide

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Multimodal analgesia is safer and more effective than PCA after minimally-invasive TKA

J Arthroplasty. 2014 Feb;29(2):329-34. doi: 10.1016/j.arth.2013.06.005. Epub 2013 Jul 11.

RCT Arthroplasty Lower Extremity Knee Pain Hydromorphone Ondansetron Metoclopramide Minimally-Invasive TKA Multimodal Analgesic Regimen Patient-Controlled Analgesia PCA - Hide

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Postoperative analgesic effect of multimodal shoulder injection after rotator cuff repair

Knee Surg Sports Traumatol Arthrosc. 2013 Dec;21(12):2877-83. doi: 10.1007/s00167-012-2202-4. Epub 2012 Sep 19

RCT Shoulder & Elbow Upper Extremity Shoulder Muscle Rotator Cuff Tear Tears Wooyoung Medical Accufuser Plus Fentanyl Ketorolac Analgesic Arthroscopic Injection Intravenous Patient-Controlled Analgesia IV PCA Multimodal - Hide

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Improved pain and patient satisfaction with periarticular multimodal drug injection in TKA

J Bone Joint Surg Am. 2006 May;88(5):959-63

RCT Arthroplasty Lower Extremity Knee Pain Injection Periarticular Multimodal TKA - Hide

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Steroid addition to multimodal cocktail periarticular injection safe and effective in TKA

J Orthop Surg Res. 2015 May 22;10(1):75

Meta-analysis Arthroplasty Lower Extremity Knee Glucocorticoid Drainage Multimodal Periarticular Injection ROM Steroid Unilateral TKA - Hide

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OTA 2016: Peri-incisional multimodal drug injections in femur fracture surgery

RCT Trauma Bone Femur Fracture Ropivacaine Epinephrine Morphine Injections Multimodal - Hide

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Satisfaction and adverse events improved with multimodal analgesia in elbow surgery

Orthop Traumatol Surg Res. 2013 Dec;99(8):895-901. doi: 10.1016/j.otsr.2013.09.005. Epub 2013 Oct 30

RCT Shoulder & Elbow Osteoarthritis Appendicular Upper Extremity Upper Extremity Elbow Joint Ligament Arthritis Dislocation Fracture Pain Ropivacaine Epinephrine Ketorolac Oxycodone Butorphanol Multimodal Analgesia Patient-Controlled Analgesia - Hide

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Beneficial effect on pain & ROM with periarticular multimodal drug injection in TKA & THA

J Arthroplasty. 2013 Dec;28(10):1882-7. doi: 10.1016/j.arth.2013.06.031. Epub 2013 Aug 1

Meta-analysis Arthroplasty Lower Extremity Hip Knee Pain Analgesia Local Infiltration Opioid Periarticular Injection Periarticular Multimodal Placebo Prosthesis Replacement ROM THA TKA - Hide

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TKA: Periarticular drug injection added to standard analgesia decreases pain

Knee. 2012 Aug;19(4):253-9. Epub 2011 Apr 19

RCT Arthroplasty Lower Extremity Knee Pain Ropivacaine Analgesic Injections Control Protocol Periarticular Multimodal TKA - Hide

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Lower pain and need for opioids with IV acetaminophen vs. placebo after total hip arthroplasty

J Arthroplasty. 2019 Jun;34(6):1155-1161. doi: 10.1016/j.arth.2019.02.033

RCT Arthroplasty Lower Extremity Hip Pain Intravenous Acetaminophen IV Acetaminophen Multimodal Analgesia Protocol - Hide

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Multimodal analgesic protocol reduces postoperative pain for TKA

J Arthroplasty. 2013 Sep;28(8):1274-7

RCT Arthroplasty Osteoarthritis Lower Extremity Knee Arthritis Pain Ropivacaine Epinephrine Morphine Ketorolac Clonidine Analgesic Control Multimodal Saline Solution - Hide

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COA 2015: Adding morphine and ketorolac to periarticular multimodal injection lowers pain

RCT Arthroplasty Osteoarthritis Lower Extremity Knee Arthritis Pain Epinephrine Morphine Ketorolac Anaesthesia Multimodal Injection Periarticular Multimodal Single Anesthetic Injection - Hide

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TKA analgesic: Periarticular injection with steroids superior to those without steroids

Chin Med J (Engl). 2013 Oct;126(20):3851-5

RCT Arthroplasty Osteoarthritis Lower Extremity Knee Arthritis Celecoxib Morphine Analgesic Multimodal Periarticular Injection Standard Medial Parapatellar Arthrotomy Steroid TKA - Hide

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Neither additional IV nor oral acetaminophen enhances multimodal analgesia efficacy in TKA

J Arthroplasty. 2017 Oct;32(10):3029-3033

RCT Arthroplasty Lower Extremity Knee Hydromorphone Care Intravenous Acetaminophen IV Multimodal Analgesia Oral Acetaminophen Oral Placebo - Hide

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Periarticular multimodal drug injection safe and efficacious alternative to FNB in TKA

J Arthroplasty. 2015 Jul;30(7):1281-6.

Meta-analysis Arthroplasty Nerve Lower Extremity Knee Bone Femur Pain Analgesia Femoral Nerve Block FNB Local Infiltration Periarticular Injection Periarticular Multimodal Replacement TKA - Hide

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Similar pain, lower opioid consumption with addition of morphine to local multimodal cocktail in TKA

Medicine (Baltimore). 2019 Oct;98(41):e17503.

Meta-analysis Arthroplasty Lower Extremity Knee Pain Morphine Injections Local Infiltration Analgesia Multimodal Opioid Periarticular Injection Replacement TKA - Hide

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Analysis of analgesic treatment efficacy in elective foot and ankle surgery

J Foot Ankle Surg. 2015 Jul-Aug;54(4):625-35

Meta-analysis Foot & Ankle Foot Lower Extremity Ankle Pain Pacira Pfizer Dexamethasone Analgesia Analgesic - Hide

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Multimodal surgical site injection has no clinical benefit versus control in ankle fracture fixation

J Bone Joint Surg Am. 2019 ;():. 10.2106/JBJS.19.00293.

RCT Trauma Appendicular Lower Extremity Ankle Fracture Ropivacaine Epinephrine Anesthetic Control Multimodal Analgesic Normal Saline - Hide

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Evaluating single-dose betamethasone for analgesia after outpatient knee arthroscopy

J Anesth. 2016 Oct;30(5):803-10

RCT Sports Medicine Lower Extremity Knee Betamethasone Anaesthesia Analgesia Arthroscopy Induction Of Anesthesia Intravenous Injection Placebo - Hide

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Periarticular multimodal drug injections effective and safe analgesic for TKA

Multimodal drug cocktail an effective analgesic treatment for ACL reconstruction

Multimodal analgesia is safer and more effective than PCA after minimally-invasive TKA

Postoperative analgesic effect of multimodal shoulder injection after rotator cuff repair

Improved pain and patient satisfaction with periarticular multimodal drug injection in TKA

Steroid addition to multimodal cocktail periarticular injection safe and effective in TKA

OTA 2016: Peri-incisional multimodal drug injections in femur fracture surgery

Satisfaction and adverse events improved with multimodal analgesia in elbow surgery

Beneficial effect on pain & ROM with periarticular multimodal drug injection in TKA & THA

TKA: Periarticular drug injection added to standard analgesia decreases pain

Lower pain and need for opioids with IV acetaminophen vs. placebo after total hip arthroplasty

Multimodal analgesic protocol reduces postoperative pain for TKA

COA 2015: Adding morphine and ketorolac to periarticular multimodal injection lowers pain

TKA analgesic: Periarticular injection with steroids superior to those without steroids

Neither additional IV nor oral acetaminophen enhances multimodal analgesia efficacy in TKA

Periarticular multimodal drug injection safe and efficacious alternative to FNB in TKA

Similar pain, lower opioid consumption with addition of morphine to local multimodal cocktail in TKA

Analysis of analgesic treatment efficacy in elective foot and ankle surgery

Multimodal surgical site injection has no clinical benefit versus control in ankle fracture fixation

Evaluating single-dose betamethasone for analgesia after outpatient knee arthroscopy

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