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High-dose TXA more effective than low-dose TXA and placebo for reducing blood loss in PLIF

Eur Spine J. 2017 Nov;26(11):2851-2857

RCT Spine Stenosis Axial Skeleton Lumbar Spinal Stenosis Tranexamic Acid Bolus High-Dose TXA Interbody Fusion Low-Dose Placebo Saline - Hide

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Low- and high-dose TXA effective in reducing blood loss and transfusion needs in TKA

BMC Musculoskelet Disord. 2013 Dec 5;14:340. doi: 10.1186/1471-2474-14-340

RCT Arthroplasty Osteoarthritis Lower Extremity Knee Arthritis Zimmer NexGen Tranexamic Acid Drain Fascia Closure High-Dose Low-Dose TXA - Hide

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Multi-dose oral TXA in total knee arthroplasty reduces blood loss with no increase in complication

Int J Surg. 2019 May;65:45-51.

RCT Arthroplasty Osteoarthritis Lower Extremity Knee Arthritis Inflammation Blood Loss Oral TXA - Hide

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TXA efficacy in perioperative spinal surgery bleeding

Spine J. 2015 Apr 1;15(4):752-761.

Meta-analysis Spine Axial Skeleton Blood Loss Epsilon-Aminocaproic Acid Intraoperative Intravenous Intravenous Tranexamic Acid Intravenous TXA Placebo Reduction Transfusion - Hide

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Topical TXA found safe and effective for reduction of blood loss and transfusion in TKA

Orthopedics. 2015 May 1;38(5):315-24.

Meta-analysis Arthroplasty Lower Extremity Knee Blood Loss Control Reduction Replacement TKA TKR Topical Tranexamic Acid Topical TXA Transfusions - Hide

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AAOS 2016: Differences in blood loss noted with various TXA administration methods in TKA

RCT Arthroplasty Lower Extremity Knee Blood Loss High-Dose IA TXA Intravenous Tranexamic Acid IV Low-Dose - Hide

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IV and topical tranexamic acid protocols reduce blood loss and transfusion needs in THA

J Arthroplasty. 2018 Oct;33(10):3083-3089.e4. doi: 10.1016/j.arth.2018.06.023

Meta-analysis Arthroplasty Lower Extremity Hip Blood Loss IV Placebo Reduction THA Topical Tranexamic Acid Transfusion TXA - Hide

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Low-dose tranexamic acid does not reduce blood loss or transfusion rate in spinal surgery

J Neurosurg Anesthesiol. 2011 Oct;23(4):290-6. doi: 10.1097/ANA.0b013e31822914a1

RCT Spine Axial Skeleton Tranexamic Acid Blood Loss Fixation Low-Dose Placebo Prophylactic Saline Transfusion TXA - Hide

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Non-inferior efficacy of topical TXA to IV TXA in total knee arthroplasty patients

J Arthroplasty. 2014 Aug;29(8):1528-31

RCT Arthroplasty Osteoarthritis Lower Extremity Knee Arthritis IV TXA Topical Tranexamic Acid Topical TXA Tourniquet - Hide

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AAOS 2016: Intravenous and topical TXA yield similar efficacy and safety in THA

Meta-analysis Arthroplasty Lower Extremity Hip Tranexamic Acid THA Topical TXA - Hide

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AAOS2018: TXA effective in operative management for high-energy pelvic and femoral fractures

RCT Trauma Lower Extremity Pelvis Bone Femur Fracture Tranexamic Acid Control TXA - Hide

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COA/ICORS2019: Perioperative IA-IV TXA most effective regimen for reducing blood loss in TKA

RCT Arthroplasty Lower Extremity Knee Tranexamic Acid IA TXA Intravenous TXA IV TXA Preoperatively - Hide

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Tranexamic acid reduces blood loss and transfusions in TKA and THA

BMC Res Notes. 2013 May 7;6:184. doi: 10.1186/1756-0500-6-184

Meta-analysis Arthroplasty Lower Extremity Hip Knee Tranexamic Acid Allogeneic Allogenic Blood Loss Blood Transfusions Control Reduction Replacement THA THR TKA TKR TXA - Hide

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Patellofemoral pain: High-dose high-repetition vs low dose, low repetition exercise

Physiotherapy. 2013 Jun;99(2):126-31. doi: 10.1016/j.physio.2012.05.009. Epub 2012 Jul 24

RCT Physical Therapy & Rehab Joint Patellofemoral Pain Syndrome High-Dose Low-Dose Medical Exercise Therapy - Hide

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Increasing number of IV TXA doses further improves efficacy without increasing VTE risk in THA

J Arthroplasty. 2018 Sep;33(9):2940-2945. doi: 10.1016/j.arth.2018.04.024

RCT Arthroplasty Thromboembolism Lower Extremity Hip Aventis Sanofi Blood Loss Intravenous Tranexamic Acid IV TXA - Hide

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TXA Reduces Blood Loss in Surgeries for Fractures of the Pelvis, Acetabulum and Proximal Femur

J Orthop Trauma. 2019 Aug;33(8):371-376.

RCT Trauma Lower Extremity Pelvis Bone Femur Joint Acetabulum Fracture Tranexamic Acid Blood Loss Internal Fixation Open Reduction TXA - Hide

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Similar blood loss and lower cost with oral TXA vs. both IA TXA and IV TXA in total hip arthroplasty

J Arthroplasty. 2018 Mar;33(3):786-793

RCT Arthroplasty Lower Extremity Hip Aventis Bayer DePuy Sanofi Blood Loss IV TXA Oral Tranexamic Acid Oral TXA - Hide

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No difference between uniform and weighted dosing of TXA for hemostasis after TKA

J Arthroplasty. 2014 Sep;29(9 Suppl):186-8

RCT Arthroplasty Lower Extremity Knee Tranexamic Acid Intravenously Tourniquet Release TXA - Hide

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TXA is effective and safe for reducing blood loss and transfusion in TKA patients

Eur J Orthop Surg Traumatol. 2015 Apr;25(3):525-41

Meta-analysis Arthroplasty Lower Extremity Knee Tranexamic Acid Blood Loss Blood Transfusion Control IA IV Placebo Prevent Primary TKA Replacement TKR TXA Unilateral TKA - Hide

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Local TXA Reduces Blood Loss vs Intravenous TXA in Patients Undergoing Total Hip Replacement

Adv Ther. 2020 01-Oct;():. 10.1007/s12325-020-01454-3

RCT Arthroplasty Osteoarthritis Appendicular Lower Extremity Hip Fracture Necrosis Intravenous Tranexamic Acid Tranexamic Acid (TXA) Antifibrinolytic agent Antifibrinolytic agent Rheumatoid arthritis - Hide

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High-dose TXA more effective than low-dose TXA and placebo for reducing blood loss in PLIF

Low- and high-dose TXA effective in reducing blood loss and transfusion needs in TKA

Multi-dose oral TXA in total knee arthroplasty reduces blood loss with no increase in complication

TXA efficacy in perioperative spinal surgery bleeding

Topical TXA found safe and effective for reduction of blood loss and transfusion in TKA

AAOS 2016: Differences in blood loss noted with various TXA administration methods in TKA

IV and topical tranexamic acid protocols reduce blood loss and transfusion needs in THA

Low-dose tranexamic acid does not reduce blood loss or transfusion rate in spinal surgery

Non-inferior efficacy of topical TXA to IV TXA in total knee arthroplasty patients

AAOS 2016: Intravenous and topical TXA yield similar efficacy and safety in THA

AAOS2018: TXA effective in operative management for high-energy pelvic and femoral fractures

COA/ICORS2019: Perioperative IA-IV TXA most effective regimen for reducing blood loss in TKA

Tranexamic acid reduces blood loss and transfusions in TKA and THA

Patellofemoral pain: High-dose high-repetition vs low dose, low repetition exercise

Increasing number of IV TXA doses further improves efficacy without increasing VTE risk in THA

TXA Reduces Blood Loss in Surgeries for Fractures of the Pelvis, Acetabulum and Proximal Femur

Similar blood loss and lower cost with oral TXA vs. both IA TXA and IV TXA in total hip arthroplasty

No difference between uniform and weighted dosing of TXA for hemostasis after TKA

TXA is effective and safe for reducing blood loss and transfusion in TKA patients

Local TXA Reduces Blood Loss vs Intravenous TXA in Patients Undergoing Total Hip Replacement

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