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Pain reduction greater with 5 injections of high-dose HA vs control for plantar fasciopathy

Knee Surg Sports Traumatol Arthrosc. 2018 Mar;26(3):903-911

RCT Foot & Ankle Lower Extremity Muscle Plantar Fascia Pain Chugai Pharmaceutical Injections Control High-Dose HA Hyaluronic Acid Low-Dose Reduction - Hide

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AAOS 2016: High-dose hyaluronate reduces pain versus placebo for plantar fasciitis

RCT Foot & Ankle Lower Extremity Muscle Plantar Fascia Pain Plantar Fasciitis Injections High-Dose Hyaluronate Low-Dose Placebo - Hide

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High- and low-dose BM-MSC injection versus control for treatment of knee osteoarthritis

J Transl Med. 2016 Aug 26;14(1):246. doi: 10.1186/s12967-016-0998-2

RCT Osteoarthritis Lower Extremity Knee Arthritis Autologous Bone Marrow Injection Control High-Dose Hyaluronic Acid Low-Dose - Hide

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Patellofemoral pain: High-dose high-repetition vs low dose, low repetition exercise

Physiotherapy. 2013 Jun;99(2):126-31. doi: 10.1016/j.physio.2012.05.009. Epub 2012 Jul 24

RCT Physical Therapy & Rehab Joint Patellofemoral Pain Syndrome High-Dose Low-Dose Medical Exercise Therapy - Hide

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OARSI 2016: Similar pain relief between combined hyaluronic acid(HA)/mannitol and high MW

RCT Osteoarthritis Lower Extremity Knee Arthritis Pain Mannitol Injections HA High Molecular Weight Hyaluronic Acid Intermediate Molecular Weight Hyaluronic Acid - Hide

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Displaced femoral neck fractures: Similar mortality rates with cemented or uncemented HA

Eur J Orthop Surg Traumatol. 2014 Jan;24(1):7-14. doi: 10.1007/s00590-012-1151-4. Epub 2012 Dec 20

Meta-analysis Trauma Bone Femur Neck Fracture Blood Loss Cemented Hemiarthroplasty HA Operative Uncemented Hemiarthroplasty - Hide

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High molecular weight biological fermentation hyaluronan advantageous in knee OA treatment

Osteoarthritis Cartilage. 2006 Feb;14(2):154-62. Epub 2005 Oct 19

RCT Osteoarthritis Appendicular Lower Extremity Knee Joint Patellofemoral Tibiofemoral Ferring Sanofi Euflexxa Synvisc Viscosupplementation Hyaluronic Acid (HA) High Molecular Weight Hyaluronic Acid (HMWHA) Mid Molecular Weight Hyaluronic Acid (MMWHA) - Hide

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Improved cartilage volume in knee OA patients receiving HA following high tibial osteotomy

Knee Surg Sports Traumatol Arthrosc. 2014 Jun;22(6):1415-23

RCT Osteoarthritis Lower Extremity Knee Bone Tibia Joint Medial Compartment Arthritis Cartilage TRB Chemedica HA High Tibial Osteotomy HTO Hyaluronic Acid Injections - Hide

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High-dose vitD has no significant effect, positive or negative, compared to low-dose after TKA

RMD Open. 2018 Jul 9;4(2):e000678. doi: 10.1136/rmdopen-2018-000678

RCT Arthroplasty Osteoarthritis Lower Extremity Knee Arthritis Vitamin D3 - Hide

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AOSSM: PRP and HA produce similar clinical outcomes treating chondropathy or early knee OA

RCT Osteoarthritis Lower Extremity Knee Arthritis Chondropathy Injections HA Hyaluronic Acid Platelet Rich Plasma PRP - Hide

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Implant migration reduced in hydroxyapatite coated versus uncoated components

Acta Orthop. 2012 Apr;83(2):135-41. doi: 10.3109/17453674.2012.665330. Epub 2012 Feb 13

RCT Arthroplasty Osteoarthritis Lower Extremity Knee Bone Tibia Arthritis Cemented Cementless Coated HA Hydroxyapatite - Hide

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Similar effect observed with PRP alone or in combination with LMW- or HMW-HA in knee OA treatment

J Arthrosc Joint Surg. 2017;4(2):65-71

RCT Osteoarthritis Lower Extremity Knee Arthritis Injection HA Hyaluronic Acid Low-Molecular-Weight Platelet-Rich Plasma PRP - Hide

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Efficacy of hyaluronic acid versus steroid injection for patients with trigger finger

Arch Phys Med Rehabil. 2015 Dec;96(12):2120-7

RCT Hand & Wrist Finger Trigger Finger Upper Extremity Injections Steroid Injection HA Hyaluronic Acid Ultrasound-Guided - Hide

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Nonsignificant differences in outcome at follow-up between low and high-MW HA for knee OA

Clin Exp Rheumatol. 2005 Mar-Apr;23(2):213-8

RCT Osteoarthritis Lower Extremity Knee Arthritis Anika Wyeth Hylan Synvisc Hyaluronic Acid Intraarticular Injections Molecular Weight - Hide

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Assessment of 12-week efficacy between high and low molecular weight HA for knee OA treatment

Clin Ther. 1999 Sep;21(9):1549-62

RCT Osteoarthritis Lower Extremity Knee Arthritis Biomatrix Hylan HA High Molecular Weight Hyaluronic Acid Intraarticular Injections Low Molecular Weight Hyaluronic Acid - Hide

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AAOS2017: Intraarticular PRP vs HA injections for degenerative knee pathology

RCT Osteoarthritis Lower Extremity Knee Arthritis Chondropathy Injections HA High-Molecular-Weight Hyaluronic Acid Intraarticular Injection Leukocyte-Rich Platelet-Rich Plasma PRP - Hide

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High-dose TXA more effective than low-dose TXA and placebo for reducing blood loss in PLIF

Eur Spine J. 2017 Nov;26(11):2851-2857

RCT Spine Stenosis Axial Skeleton Lumbar Spinal Stenosis Tranexamic Acid Bolus High-Dose TXA Interbody Fusion Low-Dose Placebo Saline - Hide

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Pain reduction greater with 5 injections of high-dose HA vs control for plantar fasciopathy

AAOS 2016: High-dose hyaluronate reduces pain versus placebo for plantar fasciitis

High- and low-dose BM-MSC injection versus control for treatment of knee osteoarthritis

Patellofemoral pain: High-dose high-repetition vs low dose, low repetition exercise

OARSI 2016: Similar pain relief between combined hyaluronic acid(HA)/mannitol and high MW

Displaced femoral neck fractures: Similar mortality rates with cemented or uncemented HA

High molecular weight biological fermentation hyaluronan advantageous in knee OA treatment

Improved cartilage volume in knee OA patients receiving HA following high tibial osteotomy

High-dose vitD has no significant effect, positive or negative, compared to low-dose after TKA

AOSSM: PRP and HA produce similar clinical outcomes treating chondropathy or early knee OA

Implant migration reduced in hydroxyapatite coated versus uncoated components

Similar effect observed with PRP alone or in combination with LMW- or HMW-HA in knee OA treatment

Efficacy of hyaluronic acid versus steroid injection for patients with trigger finger

Nonsignificant differences in outcome at follow-up between low and high-MW HA for knee OA

Assessment of 12-week efficacy between high and low molecular weight HA for knee OA treatment

AAOS2017: Intraarticular PRP vs HA injections for degenerative knee pathology

High-dose TXA more effective than low-dose TXA and placebo for reducing blood loss in PLIF

OTA 2014: High-dose vitamin D vs. placebo in deficient patients with long bone fracture

ISAKOS2017: Similar 12-week outcome between high- and low-dose steroid for shoulder stiffness

AAOS 2016: Short-term benefit with PRP vs. HA in knee cartilage lesions in athletes

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