Floseal hemostatic agent reduces blood loss but not transfusion needs in TKA patients

J Arthroplasty. 2014 Oct;29(10):1950-5.

Thrombin-based hemostatic agent associated with reduced drain output & transfusion in TKA

Knee Surg Relat Res. 2014 Dec;26(4):236-40

AAOS: Thrombin-based hemostatic reduces blood loss, but not haemoglobin loss, in TKA

AAOS: Hemostatic Agent does not appear to reduce transfusion events in THA

Collagen/thrombin and autologous platelet hemostatic agent reduces transfusion during TKA

J Arthroplasty. 2012 May;27(5):695-702. Epub 2011 Oct 27

Efficacy of Floseal vs. tranexamic acid vs. control for bleeding control in patients undergoing TKA

Clinics (Sao Paulo). 2019 Nov 25;74:e1186.

EFORT: Peri-articular & intravenous TXA similar for hemostasis in total knee arthroplasty

Decreased impairment of blood coagulation through the use of low molecular-weight colloid

Korean J Anesthesiol. 2015 Aug;68(4):364-72.

Low tourniquet pressure provides similar efficacy and safety to standard tourniquet pressure in TKA

BMC Musculoskelet Disord. 2019 Jun 4;20(1):275. doi: 10.1186/s12891-019-2636-7

Local TXA Reduces Blood Loss vs Intravenous TXA in Patients Undergoing Total Hip Replacement

Adv Ther. 2020 01-Oct;():. 10.1007/s12325-020-01454-3

IV & topical TXA similarly safe & effective for reducing blood loss and transfusion in TKA

J Orthop. 2016 Mar 26;13(3):127-31

TKA: Drain-clamping with tranexamic acid decreased drained blood volume/ transfusions

BMC Musculoskelet Disord. 2012 Jul 20;13:124. doi: 10.1186/1471-2474-13-124

TKA: No effect of fibrin sealant on reducing blood loss and functional recovery

Acta Orthop. 2013 Apr;84(2):153-8. doi: 10.3109/17453674.2013.769082. Epub 2013 Jan 25

Similar Clinical Outcomes in Oral TXA vs Epsilon-Aminocaproic Acid Up to 30 Days After THA Surgery

Blood Coagul Fibrinolysis. 2021 01-Mar;():. 10.1097/MBC.0000000000001005

Combined IV and topical tranexamic acid reduces blood loss, not transfusion rate, in TKA

J Arthroplasty. 2016 Feb;31(2):542-7

Topical tranexamic acid in TKA effectively reduces blood loss in patients

J Arthroplasty. 2013 Sep;28(8 Suppl):78-82

Preop oral TXA demonstrates noninferiority to IV TXA in TKA for hemostasis

J Arthroplasty. 2016 Sep;31(9 Suppl):26-30

Thrombin-JMI in TKA minimizes hemoglobin reduction but may not be cost effective

J Arthroplasty. 2013 Sep;28(8):1278-81

No effect of topical fibrinogen spray on blood loss and transfusion in TKA

Clin Orthop Relat Res. 2014 Jan;472(1):272-6. doi: 10.1007/s11999-013-3036-1

Three doses of 15mg/kg IV TXA reduces blood loss vs. placebo in trochanteric fracture surgery

Hong Kong Med J. 2019 Apr;25(2):120-126.