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Meta-analysis
ACE Report #9492
Ace Report Cover Arthroplasty

Combined IV-topical TXA more effective than IV TXA alone in total hip and knee arthroplasty


Study Type:Meta-analysis/Systematic Review
OE Level Evidence:1
Journal Level of Evidence:N/A

Combined intravenous and topical tranexamic acid versus intravenous use alone in primary total knee and hip arthroplasty: A meta-analysis of randomized controlled trials

Int J Surg. 2016 Dec;36(Pt A):324-329

Contributing Authors: Y Wang H. Wang J Shang B Zheng M Rui

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Synopsis

Five randomized controlled trials were included in this meta-analysis investigating the efficacy and safety of combined intravenous-intraarticular tranexamic acid administration to that of intravenous tranexamic acid alone. Pooled results demonstrated significantly lower total blood loss, smaller postoperative hemoglobin drop, and lower incidence of transfusion in combined intravenous-intraarticul...

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