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Meta-analysis
ACE Report #9219
Ace Report Cover Osteoarthritis

Consistent pain improvement from 4-24 weeks with hyaluronic acid in knee osteoarthritis


Study Type:Meta analysis
OE Level Evidence:1
Journal Level of Evidence:N/A

Therapeutic trajectory following intra-articular hyaluronic acid injection in knee osteoarthritis - meta-analysis

Osteoarthritis Cartilage. 2011 Jun;19(6):611-9

Contributing Authors: RR Bannuru NS Natov UR Dasi CH Schmid TE McAlindon

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Synopsis

54 randomized controlled trials were included in this meta-analysis evaluating the efficacy of intra-articular hyaluronic acid (IAHA) injections versus intra-articular placebo in the treatment of knee osteoarthritis. The pooled analysis of the change in pain scores significantly favoured IAHA over IA placebo at 4, 8, 12, 16, 20 and 24 weeks. The function and stiffness results favoured IAHA at 4 we...

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