Combination therapy improves site-specific BMD vs. teriparatide & denosumab monotherapies

Study Type:Therapy

OE Level Evidence:2

Journal Level of Evidence:N/A

Response to Therapy With Teriparatide, Denosumab, or Both in Postmenopausal Women in the DATA (Denosumab and Teriparatide Administration) Study Randomized Controlled Trial

J Clin Densitom. 2016 Jul-Sep;19(3):346-51

Contributing Authors: BZ Leder JN Tsai RM Neer AV Uihlein PM Wallace SA Burnett-Bowie

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Synopsis

94 postmenopausal osteoporotic women were randomized to receive either 60mg denosumab subcutaneously every 6 months, 20ug teriparatide subcutaneously daily, or a combination treatment of both 60mg denosumab and 20ug teriparatide for a duration of 24 months. The purpose of this study was to compare the individual response rates of the three treatment groups in terms of increases in bone mineral den...