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Tanezumab in Japanese patients with moderate to severe osteoarthritis of the knee
August 2013
Tanezumab in Japanese patients with moderate to severe osteoarthritis of the knee
Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A
Preliminary assessment of the safety and efficacy of tanezumab in Japanese patients with moderate to severe osteoarthritis of the knee: A randomized, double-blind, dose-escalation, placebo-controlled study
Osteoarthritis Cartilage; 2011;19(12):1405-1412Synopsis
83 Japanese patients with moderate to severe osteoarthritis of the knee were randomized to receive either tanezumab 10, 25, 50, 100 or 200 mg/kg or a placebo. The results from 120 day follow-up indicated that stronger doses of tanezumab result in significantly better pain relief in comparison to baseline measurements. However, the results from the study also indicated that adverse events occurred ...
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