Efficacy of dexmedetomidine vs. placebo for postoperative opioid use after TKA
Dexmedetomidine during total knee arthroplasty performed under spinal anesthesia decreases opioid use: a randomized-controlled trialCan J Anaesth. 2016 May;63(5):569-576.
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40 patients scheduled for primary unilateral TKA were randomized to undergo the procedure with spinal anaesthesia with or without a loading dose of intravenous dexmedetomidine. The purpose of this study was to determine if dexmedetomidine was associated with significantly decreased postoperative consumption of morphine when compared to placebo up to 24 hours postoperatively. Secondary outcomes of ...
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