Efficacy of combined teriparatide & denosumab vs. single-drug treatment for osteoporosis

Study Type:Therapy

OE Level Evidence:2

Journal Level of Evidence:N/A

Effects of Two Years of Teriparatide, Denosumab, or Both on Bone Microarchitecture and Strength (DATA-HRpQCT study)

J Clin Endocrinol Metab. 2016 May;101(5):2023-30

Contributing Authors: JN Tsai AV Uihlein SM Burnett-Bowie RM Neer NP Derrico H Lee ML Bouxsein BZ Leder

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Synopsis

94 postmenopausal women with osteoporosis were randomized to receive either teriparatide, denosumab, or a combination of the two treatments. The purpose of this study was to determine the effectiveness of combined therapy with regards to bone microarchitecture and estimated strength. Findings indicated that combination therapy of teriparatide and denosumab significantly improved most volumetric bo...