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RCT
ACE Report #9023
Ace Report Cover Pediatric Orthopaedics

Vitamin D supplementation for bone mineral density increase in osteogenesis imperfecta


Study Type:Randomized Trial
OE Level Evidence:2
Journal Level of Evidence:N/A

Effect of high-dose vitamin D supplementation on bone density in youth with osteogenesis imperfecta: A randomized controlled trial

Bone. 2016 May;86:36-42

Contributing Authors: L Plante LN Veilleux FH Glorieux H Weiler F Rauch

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Synopsis

60 youth and adolescent patients with osteogenesis imperfecta (OI) were randomized to either high-dose vitamin D supplementation (2000IU daily) or low-dose vitamin D supplementation (400IU daily). The purpose of this study was to evaluate if high-dose supplementation led to a significant increase in areal bone mineral density (aBMD) z-score of the lumbar spine compared to low-dose supplementation ...

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