WCO-IOF 2016: Denosumab versus zoledronic acid following oral bisphosphonate therapy

Study Type:Randomized Trial

OE Level Evidence:N/A

Journal Level of Evidence:N/A

A randomized double-blind study of denosumab (DMAB) compared with zoledronic acid (ZOL) in postmenopausal women with osteoporosis previously treated with oral bisphosphonates

Contributing Authors: P Miller N Pannacciulli JP Brown E Czerwinski BS Nedergaard MA Bolognese J Malouf HG Bone JY Reginster A Singer C Wang RB Wagman SR Cummings

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Synopsis

643 postmenopausal women with osteoporosis who had been administered oral bisphosphonates for 2 or more years prior to enrollment were randomized to be administered either denosumab or zoledronic acid. The purpose of this study was to compare the change in bone mineral density (BMD) and bone turnover markers after 1 year. Results demonstrated a significantly greater percent increase in BMD - inclu...