WCO-IOF 2016: Daily subcutaneous abaloparatide vs teriparatide & placebo for osteoporosis

Study Type:Randomized Trial

OE Level Evidence:N/A

Journal Level of Evidence:N/A

Effects of abaloparatide on vertebral, nonvertebral, major osteoporotic and clinical fracture incidence in postmenopausal women with osteoporosis: result of the phase 3 ACTIVE trial

Contributing Authors: LA Fitzpatrick P Miller F Cosman D Black E Lau CAF Zerbini BJ Riis C Christiansen G Williams MY Hu G Hattersley

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Synopsis

2463 postmenopausal women with osteoporosis were randomized to one of three groups: daily subcutaneous abaloparatide (80ug), daily subcutaneous teriparatide (20ug), or daily subcutaneous placebo. The treatment period was 18 months, and patients were assessed for bone mineral density and incident fracture rate. Abaloparatide treatment was reported to result in a significantly greater increase in bo...