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ACE Report #8837
Ace Report Cover Osteoarthritis

OARSI 2016: Similar pain relief between combined hyaluronic acid(HA)/mannitol and high MW

Study Type:Randomized Trial
OE Level Evidence:N/A
Journal Level of Evidence:N/A

Safety and efficacy of intra articular injections of a combination of hyaluronic acif and mannitol (HANOX-M) in patients with symptomatic knee osteoarthritis. Results of a double-blind, controlled, multicenter, randomized trial.

Contributing Authors: T Conrozier N Afif R Lecurieux A Walliser X Chevalier

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This ACE Report is a summary of a conference presentation or abstract. The information provided has limited the ability to provide an accurate assessment of the risk of bias or the overall quality. Please interpret the results with caution as trials may be in progress and select results may have been presented.


205 patients with radiological grade 1-3 knee osteoarthritis were randomized to three weekly intra-articular injections of either a combination of intermediate molecular weight hyaluronic acid and high concentration mannitol, or high molecular weight hyaluronic acid alone. The purpose of this study was to determine whether the combination of intermediate molecular weight hyaluronic acid and mannit...

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