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ACE Report #83
Ace Report Cover Arthroplasty

TKR: Topical application of tranexamic acid reduces postoperative blood loss

Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A

Topical application of tranexamic acid reduces postoperative blood loss in total knee arthroplasty: A randomized controlled trial

J Bone Joint Surg Am. 2010 Nov 3;92(15):2503-13.

Contributing Authors: J Wong A Abrishami H El Beheiry NN Mahomed J Roderick Davey R Gandhi KA Syed S Muhammad Ovais Hasan Y De Silva F Chung

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124 patients undergoing cemented total knee arthroplasty were randomized to receive either tranexamic acid (1.5g or 3.0g) or placebo saline solution, applied topically to the knee right at the end of surgery with an aim to determine the reduction of postoperative blood loss. It was observed that the treatment with tranexamic acid reduced postoperative blood loss.

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