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Hyaluronan injections provide no benefit over placebo for the treatment of osteoarthritis
January 2016
Hyaluronan injections provide no benefit over placebo for the treatment of osteoarthritis
Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A
Intra-articular hyaluronan is without clinical effect in knee osteoarthritis: a multicentre, randomised, placebo-controlled, double-blind study of 337 patients followed for 1 year
Ann Rheum Dis. 2010 Jun;69(6):1097-102Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
335 patients with knee osteoarthritis were randomized to receive either intra-articular hyaluronan or placebo injections. The purpose of this study was to investigate the long-term efficacy and safety of five intra-articular hyaluronan injections compared with placebo injections. Primary outcome was the "time to recurrence" in each group, assessed via the Lequesne Algofunctional Index (AFI). Resul...
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