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ACE Report #8136
Ace Report Cover Osteoarthritis

Effects of combining hyaluronic acid molecular weights in knee osteoarthritis

Study Type:Therapy
OE Level Evidence:1
Journal Level of Evidence:N/A

Combining two hyaluronic acids in osteoarthritis of the knee: a randomized, double-blind, placebo-controlled trial

Clin Rheumatol. 2008 Aug;27(8):975-81.

Contributing Authors: RJ Petrella A Cogliano J Decaria

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200 patients diagnosed with knee osteoarthritis were randomized to receive either high, low or combined molecular weight hyaluronic acid (HA) or a saline placebo as an intra-articular injection. The purpose of this study was to determine if varying the molecular weights and concentration of HA would have varying effects on pain relief and patient satisfaction. Results indicated that use of combine...

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