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RCT
ACE Report #7955
Ace Report Cover Metabolic Disorders

Denosumab reduces secondary fragility fracture risk in osteoporotic women


Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A

Treatment with denosumab reduces secondary fracture risk in women with postmenopausal osteoporosis

Climacteric. 2015 Jun 1:1-23

Contributing Authors: S Palacios L Kalouche-Khalil R Rizzoli C Zapalowski H Resc JD Adachi JC Gallagher RG Feldman DL Kendler A Wang RB Wagman S Adami

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Synopsis

7808 osteoperotic women part of the FREEDOM study, were analyzed in this post-hoc analysis. The purpose of this study was to determine how efficacious denosumab (60mg for 36 months) was in preventing fragility fractures and secondary fragility fractures as compared to a placebo. Results indicated that prior fragility fracture was present in 45% of the population, and denosumab treatment significan...

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