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ACE Report #7918
Zoledronate reduces radiation-induced bone collagen degradation in radiation therapy
How to Cite
OrthoEvidence. Zoledronate reduces radiation-induced bone collagen degradation in radiation therapy. ACE Report. 2020;9(8):13. Available from: https://myorthoevidence.com/AceReport/Report/7918
Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A
Effects of zoledronate on the radiation-induced collagen breakdown: a prospective randomized clinical trial
Clin Transl Oncol. 2015 Jun;17(6):454-61.Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
Forty patients with skeletal metastasis who were scheduled to undergo local radiotherapy were included in this study. The purpose of the study was to determine the effect of zoledronate, a bisphosphonate, in collagen breakdown and bone loss secondary to radiation therapy. Patients were randomized to receive the first dose of the zoledronate either before, or after radiotherapy treatment. Findings ...
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