Visit our Evidence-Based Covid-19 Website and Stay Up to Date with the latest Research.
Volume:9 Issue:8 Number:13 ISSN#:2564-2537
ACE Report #7918
Ace Report Cover Tumour

Zoledronate reduces radiation-induced bone collagen degradation in radiation therapy

How to Cite

OrthoEvidence. Zoledronate reduces radiation-induced bone collagen degradation in radiation therapy. ACE Report. 2020;9(8):13. Available from: https://myorthoevidence.com/AceReport/Report/7918

Study Type:Therapy
OE Level Evidence:2
Journal Level of Evidence:N/A

Effects of zoledronate on the radiation-induced collagen breakdown: a prospective randomized clinical trial

Clin Transl Oncol. 2015 Jun;17(6):454-61.

Contributing Authors: M Gierloff M Reutemann A Gülses P Niehoff J Wiltfang Y Açil

Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here


Forty patients with skeletal metastasis who were scheduled to undergo local radiotherapy were included in this study. The purpose of the study was to determine the effect of zoledronate, a bisphosphonate, in collagen breakdown and bone loss secondary to radiation therapy. Patients were randomized to receive the first dose of the zoledronate either before, or after radiotherapy treatment. Findings ...

To view the full report, start your 30-day free trial today

No credit card required

JOIN Forgot Password?

Not sure if you want to join OrthoEvidence?

Access this report without an Account.

Success, an email containing a link to access this report has been sent to your inbox.

CME Image

Continuing Medical Education Credits

You could be earning 0.5 CME credits for each report you read.

For Reprints and Permissions, click here

Please Login or Join to leave comments.