Zoledronate reduces radiation-induced bone collagen degradation in radiation therapy

Study Type:Therapy

OE Level Evidence:2

Journal Level of Evidence:N/A

Effects of zoledronate on the radiation-induced collagen breakdown: a prospective randomized clinical trial

Clin Transl Oncol. 2015 Jun;17(6):454-61.

Contributing Authors: M Gierloff M Reutemann A Gülses P Niehoff J Wiltfang Y Açil

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Synopsis

40 patients with skeletal metastasis who were scheduled to undergo local radiotherapy were included in this study. The purpose of the study was to determine the effect of zoledronate, a bisphosphonate, in collagen breakdown and bone loss secondary to radiation therapy. Patients were randomized to receive the first dose of the zoledronate either before, or after radiotherapy treatment. Findings ind...