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Bisphosphonates for fracture prevention in osteogenesis imperfecta patients
November 2015
Bisphosphonates for fracture prevention in osteogenesis imperfecta patients
Study Type:Meta analysis
OE Level Evidence:1
Journal Level of Evidence:N/A
Bisphosphonates for the Prevention of Fractures in Osteogenesis Imperfecta: Meta-Analysis of Placebo-Controlled Trials
J Bone Miner Res. 2015 May;30(5):929-33Did you know you're eligible to earn 0.5 CME credits for reading this report? Click Here
Synopsis
6 randomized controlled trials (RCTs) with a total of 424 subjects and 751 patient-years of follow-up were included in this meta-analysis. The purpose of this study was to determine the effectiveness of bisphosphonates in the prevention of fractures in patients with osteogenesis imperfecta. Pooled results demonstrated that bisphosphonates did not significantly reduce the proportion of patients wit...
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